- Obstetricians & Gynecologists, Yankton - Ob-Gyn Doctors, Physicians & Surgeons (Obstetrics & Gynecology)
- Office Supplies, Equipment & Office Furniture Stores, Yankton
- Oil & Petroleum Products, Yankton - Merchant, Wholesalers, etc
- Oil Change & Lubrication, Yankton - Auto Oil & Quick Lube
- Oncologists, Yankton - Cancer Doctors, Physicians & Surgeons (Oncology)
- Ophthalmologists, Yankton - Eye Doctors, Physicians & Surgeons (Ophthalmology)
- Optical Stores - Eyeglasses, Lenses & Sunglasses, Yankton
- Opticians, Yankton
- Optometrists, Yankton - Eye Doctors, Physicians & Surgeons (Optometry)
- Oral Surgeon, Yankton - Dentists - Oral & Maxillofacial Surgeons
- Ornamental Greenhouses, Yankton
- Ornamental Nursery, Yankton
- Ornamental Nursery Services, Yankton
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- Orthodontist, Yankton - Teeth Straightening, Invisalign & Dental Braces
- Orthopedic Appliances, Yankton
- Orthopedists, Yankton - Orthopedic Surgery Doctors, Physicians & Surgeons
- Other Attorneys & Lawyers, Yankton
- Other Attorneys & Lawyers, Yankton
- Other Building Materials & Supplies, Yankton
- Other Lawyers & Attorneys, Yankton
- Other Lodging, Yankton
- Outdoor & Lawn & Garden Equipment Repair & Service, Yankton
- Outdoor Equipment & Accessories, Yankton
- Outdoor Furniture & Patio Furniture, Yankton - Garden Furniture Stores
- Oxygen & Respiratory Equipment & Supplies, Yankton - Oxygen Concentrator, Tank, Machine, etc
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