- Salvage Yards, Sisseton - Auto, Motorcycle, Boat, Trucks, etc
- Sandwich Shop Restaurants, Sisseton
- Savings & Loan Associations, Sisseton
- Savings Banks, Sisseton
- Secondary Schools, Sisseton
- Security & Commodity Brokers, Sisseton
- Senior Citizens Service & Health Organizations, Sisseton
- Shelter Associations, Sisseton
- Shopping & Shopping Services, Sisseton
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- Social Services & Welfare, Sisseton
- Specialty Animal Services, Sisseton
- Specialty Stores, Sisseton
- Staffing & Support Services, Sisseton
- State Government, Sisseton
- Stoves & Furnace Equipment, Sisseton - Fittings & Repair Parts
- Substance Abuse Clinics, Sisseton - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Support Services, Sisseton
- Swimming Pools, Sisseton
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